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1994-09-05
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Document 0854
DOCN M9480854
TI Immune and serologic profiles of HIV-infected and non-infected
hemophilic children and adolescents. HGDS.
DT 9410
AU Jason J; Murphy J; Sleeper LA; Donfield SM; Warrier I; Arkin S; Evatt B;
Gomperts ED; CDC, Atlanta, GA.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-10). Unique
Identifier : AIDSLINE ASM94/94313091
AB To assess relationships among HIV's effects on hemophilic children and
adolescents' immunologic parameters and vaccine-related serology, we
analyzed extensive baseline immunologic evaluations of 207 HIV
antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic
children and adolescents. All group comparisons were age-adjusted. HIV+,
compared to HIV-, participants had lower CD4+ lymphocyte counts
(medians: HIV+ 423/microliters, HIV- 895/microliters; p < .0001), NK
cell counts (medians: HIV+ 109/microliters, HIV- 210/microliters; p <
.0001), and CD19+ lymphocyte counts (medians: HIV+ 229/microliters, HIV-
387/microliters; p < .0001). The HIV+ participants also had higher CD8+
lymphocyte counts (medians: HIV+ 841/microliters, HIV- 678/microliters;
p = .001) and serum immunoglobulin levels (IgG 1788 vs 1232 mg/dL, p <
.0001; IgA 219 vs 156 mg/dL, p < .0001; IgM 141 vs 114 mg/dL, p = .0199.
Seroprevalence rates for diphtheria toxoid, measles, and mumps antigens
were significantly lower in the HIV+ group compared to the HIV- group.
IgG levels, IgM levels, and serologic titers to vaccine antigens showed
little correlation with T cell parameters. HIV had significant, largely
independent T- and B-lymphocyte effects on this pediatric cohort. The
effects of HIV on infected hemophilic youth in this study are severe,
broad, and not necessarily all secondary to infection of CD4+
lymphocytes. Our results support additional, independent effects on
B-lymphocytes, antigen presenting cells, and/or cytokine production.
DE Adolescence Antigens, CD/BLOOD Antigens, Differentiation,
B-Lymphocyte/BLOOD Antigens, Viral/BLOOD B-Lymphocytes/IMMUNOLOGY
Child Cohort Studies Comparative Study
Hemophilia/BLOOD/COMPLICATIONS/*IMMUNOLOGY Human HIV
Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY HIV Seronegativity HIV
Seropositivity/BLOOD/*IMMUNOLOGY IgG/BLOOD IgM/BLOOD Killer Cells,
Natural/IMMUNOLOGY Lymphocytes/*IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).